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For Sheriff Norris Cunningham, the lock down is a nightmare. The Pandemic has cast a darkness over his life, his job and the village he holds dear. One morning he enters the house of Nicholas Murphy, whose daughter turned fanatic, shot her mother and brutally assaulted her father before dying. The Mayor wants to bury this case, but the violent behavior and unnatural death of the daughter bothers Cunningham and he seeks help from Medical Examiner Dr. William Sterling. But this is no ordinary murder, and leads to traces of a neurological contagion that changes brain chemistry and breeds paranoia and fear. To prevent violence, Cunningham urges the villagers to hand over their firearms, but his strategy backfires. To make matters worse, they discover one significant factor far too late. And before his eyes, the entire village turns into a mob of mindless zombies marching towards the city of New York.